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KMID : 0352819930090010041
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Kosin Medical Journal
1993 Volume.9 No. 1 p.41 ~ p.60
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Morphologic Effect of Calcium Channel-blocker(Verapamil) on Cyclosporine ACephrotoxicity
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Abstract
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Effect of calcium channel blocker(CB) on cyclosporin A(C) nephrotoxicity was investigated in the Male Wister rat in a 4-week experiment at the light and electron microsoopic level. To accomplish the aim of this study, 25 week old male Wister rats
were
divided into following 3 experimental groups; 1 CsA(50mg/kg/ady) alone daily per os; 2. CsA(50mg/kg/day) concomitantadministration of CB verapamil(20mg/kg/day) daily per os;3. CsA(50mg/kg/day) concomitant administration of verapmil(10mg/kg/day)
daily
per os.
Morphologically, Csa nephrotoxicity was chara cterized bythe following features;(1) tubular inclusion bodies correspoding to predominate polymorphous outolysosomes and a small number of markedly enlarged mitochondria;(2) tubular vacuolization due
to
dilation of the rough and smooth endoplasmic reticulum;(3) tubular microcalcification. These morphologic features were imited to the proximal tubules.
Simultaneous administration of CB verapamil with CsA reduced CsA induced morphologic damage of the proximal tubules of the kidney; especially tubular inclusion bodies were significantly reduced, independent of the dosage of the verapamil.
These histopathological findings are interpretedds morphological manifestations of the effetc of calcium channel blocker, verapamil ameliorating CsA nephrotoxicity.
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